A black cartridge containing a paper-based diagnostic for detecting the Zika virus is held up by a researcher at Harvard's Wyss Institute. Areas that have turned purple indicate samples infected with Zika, while yellow areas indicate samples that are free of the virus.

A black cartridge containing a paper-based diagnostic for detecting the Zika virus is held up by a researcher at Harvard's Wyss Institute. Areas that have turned purple indicate samples infected with Zika, while yellow areas indicate samples that are free of the virus.
Photo Credit: Wyss Institute at Harvard University

New test for Zika could be used in remote places

Canadian and U.S. researchers have created a quick and inexpensive test for the Zika virus that does not require refrigeration. The paper-based test could eventually be used to screen blood, urine or saliva samples and could be programmed to detect other pathogens as well. The work was published in the journal Cell and involved scientists from MIT, Harvard University, Cornell University and the University of Toronto.

University of Toronto researcher Keith Pardee says the new test for Zika virus performs the same functions as a laboratory.
University of Toronto researcher Keith Pardee says the new test for Zika virus performs the same functions as a laboratory. © Canadian Press/hand out photo University of Toronto.

‘A lab on a chip’

“It’s basically a lab on a chip, is a way to think of it,” says Keith Pardee, a lead author of the paper and an assistant professor at the University of Toronto. “We’ve designed three molecular components that functionally perform the same steps that you would have done in a clinical lab at hospital.”

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The Zika virus is transmitted by the Aedes mosquito and by sexual contact with an infected person. Where it has infected pregnant women, babies have been born with abnormally small heads and brain disorders. Some infected adults have developed Guillain-Barré syndrome where the immune system attacks nerves, sometimes leading to paralysis.

Test would help curb spread

Detection of Zika is important to those who are infected so they can get quick

On Feb. 12, 2016, baby Lara who was born with microcephaly was examined at a hospital in Brazil. An outbreak of Zika is believed responsible for thousands of such birth defects in that country.
On Feb. 12, 2016, baby Lara who was born with microcephaly was examined at a hospital in Brazil. An outbreak of Zika is believed responsible for thousands of such birth defects in that country. © Felipe Dana/AP Photo file

access to treatment. From a public health perspective, the test would enable officials to track the disease. They could isolate infected individuals to prevent them from being bitten by mosquitoes who could then transmit the virus to others.

The new test needs to pass regulatory hurdles before it can be made available. Researchers are seeking public and private partners to help. The best case scenario is that the test could be available in a few months. It costs between 60 cents and one dollar to make now, but the cost could go down with larger production runs.

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